HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Extracellular RNA mediates endothelial-cell permeability via vascular endothelial growth factor
نویسندگان
چکیده
1Department of Biochemistry Medical School, Justus-Liebig-University, Giessen; 2Department of Anesthesiology, Department of Experimental Neurology, Kerckhoff-Klinik, Bad Nauheim; 3Department of Neurology, Medical School, Justus-Liebig-University, Giessen; 4Department of Radiology, Department of Experimental Neurology, Kerckhoff-Klinik, Bad Nauheim; 5Core Lab for Molecular and Structural Biology, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim; 6Charité–Universitätsmedizin, Department of Internal Medicine/Infectious Pulmonary Diseases, Berlin, Germany
منابع مشابه
Extracellular RNA mediates endothelial-cell permeability via vascular endothelial growth factor.
Cell injury leads to exposure of intracellular material and is associated with increased permeability of vessels in the vicinity of the damage. Here, we demonstrate that natural extracellular RNA as well as artificial RNA (poly-I:C), or single-stranded RNA but not DNA, significantly increased the permeability across brain microvascular endothelial cells in vitro and in vivo. RNA-induced hyperpe...
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